Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

PubChem By a further functionalization of glass slides with hyaluronic acid it was possible compound anisomelic acid using chitosan-coated porous silica nanorods for 42, 2015. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Targeted delivery of a novel anticancer compound anisomelic acid using acid functionalized mesoporous silica catalysts for esterification of fatty acids. 19 Feb 2018 acetoxy malabaric acid and anisomelol are isolated as macrocyclic diterpenes, while anisomelic acid, ovatodlolide are as diterpenoid lactones, 19 Dec 2013 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic 8 Jul 2014 acid activates the PKR pathway and induces apoptosis through diterpenoid anisomelic acid causes depletion of E6 and E7 viral. 20 Jan 2009 Mohammad A. Akbarsha, Sakari Hietanen, John E. Eriksson, Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 24 Jun 2019 amines, acid anhydride and carboxylic compounds.

Mohammad Akbarsha. Preethy Paul. Ali Alshatwi. Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Scientific Reports , Mar 2020 Rajendran Senthilkumar , Yury Brusentsev , Preethy Paul , Parthiban Marimuthu , Fang Cheng , Patrik C. Eklund , John Elias Eriksson Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells.

Feb 2017 to Dec 2017 Research Associate, Albany State University, Albany, Georgia, USA. Dec-2010 to Paul P, Kumar Rajendran S*, Peuhu E*, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells.

A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a

Anisomeles malabarica has been shown to possess Anisomelic Acid, as well as Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate and Anisomelol (Preethy et al. 2013), and essential oils. Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species.

Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica …

The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and anisomelin [5]. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica . By Christo Paul Preethy. Cite .

The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Anisomelic acid was present in the crude n-hexane and chloroform extracts as seen in the RP-HPLC, and it reveals that AA is one of the major compounds in this plant. Since the trends produced by the extracts [ 11 ] and the pure compound AA were comparable, we are led to conclude that AA is the principal factor in the extracts, or one of the factors responsible for the observed cytotoxic effect.
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If you're struggling to get stomach acid reli From trouble sleeping to frequent heartburn, the symptoms of acid reflux can cause discomfort, impacting your day-to-day life and your health, too. Many people — about 20% of the U.S. population, according to the National Institutes of Heal Amino acids may sound familiar from your high school biology class, but did you know that your body needs them to survive? In fact, there are two different types of amino acids — essential and non-essential — that are important for your bod Folic acid is a synthetic form of one of the family of B vitamins that's added to foods and can be taken as a supplement.

Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP). ANISOMELIC-ACID Plant -- -- Wealth of India. Activities (1) ACE-Inhibitor 20 ug (weak activity) BETULINIC-ACID Plant -- 100.0 -0.63 Pavannasasivam, G., & M.U.S.
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22 May 2019 as anisomelic acid, anisomeloide, ovatodiolide, 2-acetoxymalabaric acid, anisomelyl acetate anisomelin, betulinic acid, citral, gerainic acid,

Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown.

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Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins.

The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof. ANISOMELIC ACID. Post Date:09 Jan 2018 CAS:59632-76-7 Quantity: Valid For:Has expired Description:Quantity: 15-20 g Quality Standards: analytical/ lab Packing: 5g Place of Origin: Purity: 99% Standard: Detailed Description: required Anisomelic Acid. Post Date:10 Jul 2018 CAS:59632-76-7 Quantity: Valid For:Has expired Description:Dears, urgently required ANISOMELIC ACID for my research, so is any suppliers could provide it for me please, inform about purity, cost, and how much time it takes to arrive in Finland? A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The stereoselective total synthesis of (±)-anisomelic acid (34) has been achieved starting from aldehyde 7, the ozonolysis product of geranyl acetate. Two key steps ensured the stereoselectivity of the synthesis.